Abstract: Tackling the Grand Challenge of understanding, predicting, and managing turbulent transport remains critical in fusion research. Nonlinear gyrokinetic simulations are paramount for precise and dependable forecasts. Recent breakthroughs now permit whole-device modeling, extending from the magnetic axis to the material walls. Additionally, the adoption of code coupling techniques has notably expedited the profile prediction process for large fusion devices like ITER. Concurrently, a suite of multi-fidelity techniques are in development, which promise to drastically cut down computational requirements by several magnitudes, allowing for the development of flight simulators and potentially reaching real-time control capabilities. Utilizing these strategies paves the way for optimizing the design of future fusion power plants, thereby propelling the field of fusion research forward.